Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Author Siqueira, Lilian Autor UNIFESP Google Scholar
de Paula, Cynthia Guimaraes Autor UNIFESP Google Scholar
Motisuke, Mariana Autor UNIFESP Google Scholar
Gouveia, Rubia Figueredo Google Scholar
Afonso Camargo, Samira Esteves Google Scholar
Moreira Milhan, Noala Vicensoto Google Scholar
Triches, Eliandra de Sousa Autor UNIFESP Google Scholar
Abstract Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.
Keywords Tricalcium phosphate
alumina
gel-casting method
cytocompatibility
scaffolds
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Carlos
Language English
Sponsor Sao Paulo Research Foundation - FAPESP
National Council for Scientific and Technological Development
National Council for Scientific and Technological Development
Grant number FAPESP: 2010/00863-0
National Council for Scientific and Technological Development: 456461/2014-0]
CNPq/PIBITI/UNIFESP
Date 2017
Published in Materials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 20, n. 4, p. 973-983, 2017.
ISSN 1516-1439 (Sherpa/Romeo, impact factor)
Publisher Univ Fed Sao Carlos, Dept Engenharia Materials
Extent 973-983
Origin http://dx.doi.org/10.1590/1980-5373-MR-2016-0467
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000410628100016
SciELO ID S1516-14392017000400973 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/53521

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