Bombesin administration impairs memory and does not reverse memory deficit caused by sleep deprivation

Bombesin administration impairs memory and does not reverse memory deficit caused by sleep deprivation

Author Ferreira, L. B. T. Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Raya, J. Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Hipolide, D. C. Autor UNIFESP Google Scholar
Abstract Sleep deprivation impairs performance in emotional memory tasks, however this effect on memory is not completely understood. Possible mechanisms may involve an alteration in neurotransmission systems, as shown by the fact that many drugs that modulate neural pathways can prevent memory impairment by sleep loss. Gastrin releasing peptide (GRP) is a neuropeptide that emerged as a regulatory molecule of emotional memory through the modulation of other neurotransmission systems. Thus, the present study addressed the effect of intraperitoneal (IP) administration of bombesin (BB) (2.5, 5.0 and 10.0 pg/kg), a GRP agonist, on the performance of Wistar rats in a multiple trail inhibitory avoidance (MTIA) task, after sleep deprivation, using the modified multiple platforms method (MMPM). Sleep deprived animals exhibited acquisition and retention impairment that was not prevented by BB injection. In addition, non-sleep deprived animals treated with BB before and after the training session, but not before the test, have shown a retention deficit. In summary, BB did not improve the memory impairment by sleep loss and, under normal conditions, produced a memory consolidation deficit.
Keywords Modified multiple platforms method
Emotional memory
Multiple-trial inhibitory avoidance
Gastrin-releasing peptide
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, National Science and Technology Council)
Associacao Fundo de Incentivo a Pesquisa (AFIP, Funding Society for the Incentive of Research)
Grant number FAPESP
CNPq
AFIP
Date 2017
Published in Behavioural Brain Research. Amsterdam, v. 331, p. 20-24, 2017.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 20-24
Origin http://dx.doi.org/10.1016/j.bbr.2017.05.027
Access rights ACESSO RESTRITO
Type Article
Web of Science ID WOS:000404815100003
URI https://repositorio.unifesp.br/handle/11600/53433

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