Pulmonary emphysema induced by passive smoking: an experimental study in rats

Pulmonary emphysema induced by passive smoking: an experimental study in rats

Autor Cendon Filha, Sônia Perez Autor UNIFESP Google Scholar
Battlehner, Claudia Google Scholar
Lorenzi-Filho, Geraldo Google Scholar
Dohlnikoff, Marisa Google Scholar
Pereira, Patricia M Autor UNIFESP Google Scholar
Conceição, Gleice M S Autor UNIFESP Google Scholar
Beppu, Osvaldo Shigueomi Autor UNIFESP Google Scholar
Saldiva, Paulo Hilário Nascimento Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78; P<0.05). When the two groups of smoking rats were pooled together and compared to controls, they showed decreased lung elastance (1.6 vs 2.19; P = 0.046) and increased mean linear intercept (Lm) (85.14 vs 66.44; P = 0.025). The s-90 animals presented higher inflammation and muscular hypertrophy at the level of the axial bronchus than the controls (P<0.05). When smoking groups were pooled and compared to controls, they presented significantly higher inflammation at the lateral level (P = 0.028), as well as airway secretory hyperplasia (P = 0.024) and smooth muscle hypertrophy (P = 0.005) at the axial level. Due to its simplicity, low cost and short duration, this technique may be a useful model to obtain new information about airspace remodeling due to chronic tobacco consumption
Palavra-chave passive smoking
emphysema
rats
pulmonary function
morphological analysis
quantification
Idioma Inglês
Data de publicação 1997-10-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 30, n. 10, p. 1241-1247, 1997.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1241-1247
Fonte http://dx.doi.org/10.1590/S0100-879X1997001000017
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1997YA76600017
SciELO S0100-879X1997001000017 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/532

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