The Place of protease inhibitors in antiretroviral treatment

The Place of protease inhibitors in antiretroviral treatment

Autor Tenore, Simone de Barros Autor UNIFESP Google Scholar
Ferreira, P.r.a. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance.
Palavra-chave AIDS
antiretroviral treatment
protease inhibitors
Idioma Inglês
Data de publicação 2009-10-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 13, n. 5, p. 371-374, 2009.
ISSN 1413-8670 (Sherpa/Romeo, fator de impacto)
Publicador Brazilian Society of Infectious Diseases
Extensão 371-374
Fonte http://dx.doi.org/10.1590/S1413-86702009000500012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000277559300012
SciELO S1413-86702009000500012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5314

Exibir registro completo




Arquivo

Nome: S1413-86702009000500012.pdf
Tamanho: 289.5KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta