The effect of macadamia oil intake on muscular inflammation and oxidative profile kinetics after exhaustive exercise

The effect of macadamia oil intake on muscular inflammation and oxidative profile kinetics after exhaustive exercise

Author Malvestiti, Rosane Google Scholar
Borges, Leandro da Silva Google Scholar
Weimann, Eleine Google Scholar
da Silva Junior, Edenilson Pinto Google Scholar
Levada-Pires, Adriana Cristina Google Scholar
Dermargos, Alexandre Google Scholar
Lambertucci, Rafael Herling Autor UNIFESP Google Scholar
Hatanaka, Elaine Google Scholar
Abstract In this study, we evaluated the onset and resolution of inflammation in control and macadamia oil-supplemented rats after a single session of exhaustive exercise. We also analysed the antioxidant enzymes catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), and thiobarbituric acid reactive substances (TBARS). Rats were supplemented for ten days with macadamia oil (25 mg/kg), which is rich in oleic and palmitoleic acids. On the 10th day, control and macadamia oil-treated rats exercised to physical exhaustion. Plasma and muscular levels of pro-inflammatory cytokines (tumour necrosis factor alpha [TNF-], interleukin-1 beta [IL-1], IL-6, cytokine-induced neutrophil chemoattractant-3 [CINC-3], macrophage inflammatory protein-3-alpha [MIP-3]) and soluble L-selectin were measured prior to, immediately after, and 2, 24, and 48 h after exercise. Our data revealed increases in the muscle concentrations of IL-1, L-selectin, CINC-3, and MIP-3 in the group supplemented with macadamia oil compared with the concentrations in the control group. CAT also increased in the treated group, which is important because pro-inflammatory cytokines precede growth factor production and might alter the muscle repair process. We concluded that inflammation resulting from exhaustive exercise was greater in animals that received macadamia oil than in control animals. Practical applications: There are potential benefits of using fatty acids in the treatment of injured muscles, and these substances have been used in several types of injured tissues. Macadamia oil intake alters muscle healing signaling by influencing the production of reactive oxygen species and inflammatory mediators. Therefore, it is reasonable to hypothesize that the intake of immunomodulatory supplements would be beneficial to the muscular recovery of an athlete following a strenuous exercise session.
Keywords Cytokines
Inflammation
Muscle
Physical activity
TNF-
IL-1
Language English
Sponsor Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 14/03947-1
CNPq: 307769/2014-3
Date 2017
Published in European Journal Of Lipid Science And Technology. Hoboken, v. 119, n. 8, p. -, 2017.
ISSN 1438-7697 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent -
Origin http://dx.doi.org/10.1002/ejlt.201600382
Access rights Closed access
Type Article
Web of Science ID WOS:000407162500011
URI http://repositorio.unifesp.br/handle/11600/51472

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