Gender-based normative values for pattern-reversal and flash visually evoked potentials under binocular and monocular stimulation in healthy adults

Gender-based normative values for pattern-reversal and flash visually evoked potentials under binocular and monocular stimulation in healthy adults

Author Dotto, Patricia de Freitas Autor UNIFESP Google Scholar
Berezovsky, Adriana Autor UNIFESP Google Scholar
Sacai, Paula Yuri Autor UNIFESP Google Scholar
Rocha, Daniel Martins Autor UNIFESP Google Scholar
Salomao, Solange Rios Autor UNIFESP Google Scholar
Abstract Purpose To determine gender-based normative values for pattern-reversal (PR) and flash (F) visually evoked potentials (VEP) under binocular and monocular stimulation in healthy adults. Methods Healthy adults (age >= 18 years) were recruited among university employees and students. Inclusion criteria were absence of abnormalities in fundoscopy, tracking ability, stereopsis and pupillary reflexes

best-corrected visual acuity <=.00 logMAR

and refractive error (spherical equivalent) from -6.00 to +6.00. Exclusion criteria were previous intraocular surgery, systemic and/or neurological disorders. Binocular and monocular tests were performed according to International Society for Clinical Electrophysiology of Vision standards for PRVEP (reversal rate = 1.9 Hz, checkerboard stimuli 15' and 60' at 100% contrast) and FVEP (3 cd s/m(2), rate = 1 Hz). VEP parameters of amplitude (mu V) and peak times (ms) were measured. Inter-ocular differences, inter-peak intervals (N135-N75) and binocular summation were determined. Results Fifty-four subjects (28 females

mean age = 40.4 +/- 13.7 years

median = 40.0 years) were included. Mean P100 latencies for 15' and 60' stimuli were, respectively, 94.6 +/- 4.7 ms and 96.1 +/- 4.2 for women. Mean values of P100 latency for men were 97.4 +/- 4.9 for 15' and 97.7 +/- 4.2 for 60' stimuli. Larger mean P100 for 15' checks was observed in women (12.8 +/- 5.7 mu V) than men (8.6 +/- 2.5 mu V) in PRVEP. Similar results were found for FVEP N2-P2 amplitudes (mean = 14.6 +/- 4.9 for women and 9.8 +/- 4.0 for men). Conclusions Gender-based normative values for PRVEP and FVEP were determined, with women disclosing higher responses than men for smaller stimuli in the visual pathway. The use of gender-based normative values in the analysis of clinical VEP data for diagnostic and therapeutic purposes is recommendable. Additional analysis including inter-peak intervals and binocular summation ratio might improve the diagnostic power of VEP.
Keywords Visually evoked potentials
Gender
Normative values
Pattern reversal
Flash VEP
Visual pathways
Language English
Date 2017
Published in Documenta Ophthalmologica. Dordrecht, v. 135, n. 1, p. 53-67, 2017.
ISSN 0012-4486 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 53-67
Origin http://dx.doi.org/10.1007/s10633-017-9594-x
Access rights Closed access
Type Article
Web of Science ID WOS:000406641700005
URI http://repositorio.unifesp.br/handle/11600/51471

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