Growth of children born to renal transplanted women

Growth of children born to renal transplanted women

Author Dinelli, M. Isabel S. Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Viana, Patricia O. Autor UNIFESP Google Scholar
dos Santos, Amelia M. N. Autor UNIFESP Google Scholar
Isabel de Moraes-Pinto, M. Autor UNIFESP Google Scholar
Abstract Neonates born to transplanted mothers are exposed to immunosuppressive drugs during gestation and have a higher risk of being born prematurely and small for gestational age than the general population. We have prospectively followed up 27 children born to renal transplanted mothers from a single center and 31 healthy children born at term with adequate weight for gestational age. Comparisons of weight and length measurements were made at birth, 1 month (+/- 0.9), 3 months (+/- 1.0), 6 months (+/- 1.0), 9 months (+/- 1.5), and 12 months (+/- 1.49) of age. There were a high rate of prematurity (51.9%) and neonates small for gestational age (40.7%) in the transplant group. At birth, in the transplant group, 28% of neonates had subnormal z-scores for weight and 40%, low z-scores for length. However, at 6 months of age, no significant differences were noticed in mean weight-for-age z-scores between groups (weight -0.43 vs -0.03

length -0.53 vs -0.08). At 12 months of age, comparable mean length-for-age z-scores were observed in both groups (weight 0.01 vs 0.27

length -0.07 vs 0.26). Conclusion: Despite high rates of premature births and neonates small for gestational age in the transplant group, there was a good recovery of growth during the first year. What is Known: Children born to renal transplanted mothers are exposed to immunosuppressive drugs during gestation [4]. They have high risk of premature birth and fetal growth restriction, immune alterations at birth, and risk of hospitalization for infection in the first months of life [5]. What is New: Despite high rates of premature birth and neonates small for gestational age, these infants had good growth recovery by 1 year of age.
Keywords Fetal growth restriction
Premature birth
Immunosuppressive drugs
Infant development
Growth catch-up
Language English
Sponsor Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2008/11670-9
Date 2017
Published in European Journal Of Pediatrics. New York, v. 176, n. 9, p. 1201-1207, 2017.
ISSN 0340-6199 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1201-1207
Origin http://dx.doi.org/10.1007/s00431-017-2965-1
Access rights Closed access
Type Article
Web of Science ID WOS:000408000400007
URI http://repositorio.unifesp.br/handle/11600/51343

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