High prevalence of hepatitis E virus antibodies in Sao Paulo, Southeastern Brazil: analysis of a group of blood donors representative of the general population

High prevalence of hepatitis E virus antibodies in Sao Paulo, Southeastern Brazil: analysis of a group of blood donors representative of the general population

Author Passos-Castilho, Ana Maria Autor UNIFESP Google Scholar
Reinaldo, Monica Renata Autor UNIFESP Google Scholar
de Sena, Anne Autor UNIFESP Google Scholar
Granato, Celso F. H. Autor UNIFESP Google Scholar
Abstract Brazil is a non-endemic country for hepatitis E virus (HEV) infection with seroprevalence from 1% to 4% in blood donors and the general population. However, data on seroprevalence of HEV in the country are still limited. This study evaluated the prevalence of past or present HEV infection in a group of blood donors representative of the general population of the city of Sao Paulo, Southeastern Brazil. Serum samples from 500 blood donors were tested from July to September 2014 by serological and molecular methods. Anti-HEV IgG antibodies were detected in 49 (9.8%) subjects and categorized age groups revealed an age-dependent increase of HEV seroprevalence. Among the anti-HEV IgG positive subjects, only 1 had anti-HEV IgM while none tested positive for HEV-RNA. The present data demonstrate a higher seroprevalence of anti-HEV IgG than previously reported in the region. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.
Keywords Hepatitis E virus
Blood donors
Seroprevalence
Brazil
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2012/22925-3
FAPESP: 2013/03701-0
Date 2017
Published in Brazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 21, n. 5, p. 535-539, 2017.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Elsevier Brazil
Extent 535-539
Origin http://dx.doi.org/10.1016/j.bjid.2017.05.004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000414276300008
SciELO ID S1413-86702017000500535 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/51259

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