A century of research: what have we learned about the interaction of Trypanosoma cruzi with host cells?

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dc.contributor.author Alves, Maria Julia Manso
dc.contributor.author Mortara, Renato Arruda [UNIFESP]
dc.date.accessioned 2015-06-14T13:41:00Z
dc.date.available 2015-06-14T13:41:00Z
dc.date.issued 2009-07-01
dc.identifier http://dx.doi.org/10.1590/S0074-02762009000900013
dc.identifier.citation Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 104, p. 76-88, 2009.
dc.identifier.issn 0074-0276
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/5124
dc.description.abstract Since the discovery of Trypanosoma cruzi and the brilliant description of the then-referred to new tripanosomiasis by Carlos Chagas 100 years ago, a great deal of scientific effort and curiosity has been devoted to understanding how this parasite invades and colonises mammalian host cells. This is a key step in the survival of the parasite within the vertebrate host, and although much has been learned over this century, differences in strains or isolates used by different laboratories may have led to conclusions that are not as universal as originally interpreted. Molecular genotyping of the CL-Brener clone confirmed a genetic heterogeneity in the parasite that had been detected previously by other techniques, including zymodeme or schizodeme (kDNA) analysis. T. cruzi can be grouped into at least two major phylogenetic lineages: T. cruzi I, mostly associated with the sylvatic cycle and T. cruzi II, linked to human disease; however, a third lineage, T. cruziIII, has also been proposed. Hybrid isolates, such as the CL-Brener clone, which was chosen for sequencing the genome of the parasite (Elias et al. 2005, El Sayed et al. 2005a), have also been identified. The parasite must be able to invade cells in the mammalian host, and many studies have implicated the flagellated trypomastigotes as the main actor in this process. Several surface components of parasites and some of the host cell receptors with which they interact have been described. Herein, we have attempted to identify milestones in the history of understanding T. cruzi- host cell interactions. Different infective forms of T. cruzi have displayed unexpected requirements for the parasite to attach to the host cell, enter it, and translocate between the parasitophorous vacuole to its final cytoplasmic destination. It is noteworthy that some of the mechanisms originally proposed to be broad in function turned out not to be universal, and multiple interactions involving different repertoires of molecules seem to act in concert to give rise to a rather complex interplay of signalling cascades involving both parasite and cellular components. en
dc.format.extent 76-88
dc.language.iso eng
dc.publisher Instituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartof Memórias do Instituto Oswaldo Cruz
dc.rights Acesso aberto
dc.subject Trypanosoma cruzi en
dc.subject cellular invasion en
dc.subject trypomastigotes en
dc.subject amastigotes en
dc.subject parasitophorous vacuole escape en
dc.subject phylogenetic lineages en
dc.title A century of research: what have we learned about the interaction of Trypanosoma cruzi with host cells? en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade de São Paulo Instituto de Química Departamento de Bioquímica
dc.description.affiliation Escola Paulista de Medicina Universidade Federal de São Paulo (UNIFESP) Departamento de Microbiologia, Imunologia e Parasitologia
dc.description.affiliationUnifesp UNIFESP, EPM, EPM, Depto. de Microbiologia, Imunologia e Parasitologia
dc.identifier.file S0074-02762009000900013.pdf
dc.identifier.scielo S0074-02762009000900013
dc.identifier.doi 10.1590/S0074-02762009000900013
dc.description.source SciELO
dc.identifier.wos WOS:000269123500012

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