Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice

Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice

Author Siqueira, Camila Monteiro Google Scholar
Motta, Priscila Dias Google Scholar
Cardoso, Thayna Neves Google Scholar
Coelho, Cideli de Paula Google Scholar
Popi, Ana Flavia Autor UNIFESP Google Scholar
Couceiro, Jose Nelson Google Scholar
Bonamin, Leoni Villano Google Scholar
Holandino, Carla Google Scholar
Abstract Background: Influenza affects thousands of people worldwide every year, motivating the development of new therapies. In this work, the effects of two homeopathic preparations (influenza biotherapies and thymulin) were chosen following two different rationales: isotherapy and endo-isotherapy models. The homeopathic effects were evaluated individually considering the inflammatory and behavioral responses against influenza virus antigen were studied in BALB/c mice. Methods: Male adult mice were treated orally and blindly for 21 days with highly diluted influenza virus or with thymulin, and were divided in two sets of experiments. The first series of experiments aimed to describe their behavior, using an open field (OF) device. In the second series, mice were challenged subcutaneously with influenza hemagglutinin antigen (7 mu g/200 mu l) at day 21. At day 42, behavior and inflammation response were evaluated. Results: No behavioral changes were seen in OF tests at any time point after treatments. Flow cytometry and morphometry revealed significant changes in T and B cell balance after influenza antigen challenge, varying according to treatment. Conclusion: The results show that both homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. A deeper understanding of the mechanism could elucidate their possible use in influenza epidemiological situations.
Keywords Homeopathy
Influenza virus
Influenza hemagglutinin antigen
Behavior
Thymulin
Immunology
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Date 2016
Published in Homeopathy. Oxford, v. 105, n. 3, p. 257-264, 2016.
ISSN 1475-4916 (Sherpa/Romeo, impact factor)
Publisher Elsevier Sci Ltd
Extent 257-264
Origin http://dx.doi.org/10.1016/j.homp.2016.04.002
Access rights Closed access
Type Article
Web of Science ID WOS:000381061800008
URI http://repositorio.unifesp.br/handle/11600/51208

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