Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder

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dc.contributor.author Mansur, Rodrigo B. [UNIFESP]
dc.contributor.author Santos, Camila M. [UNIFESP]
dc.contributor.author Rizzo, Lucas B. [UNIFESP]
dc.contributor.author Cunha, Graccielle R. [UNIFESP]
dc.contributor.author Asevedo, Elson [UNIFESP]
dc.contributor.author Noto, Mariane N. [UNIFESP]
dc.contributor.author Pedrini, Mariana [UNIFESP]
dc.contributor.author Zeni, Maiara [UNIFESP]
dc.contributor.author Cordeiro, Quirino [UNIFESP]
dc.contributor.author McIntyre, Roger S. [UNIFESP]
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.date.accessioned 2019-07-22T15:46:57Z
dc.date.available 2019-07-22T15:46:57Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1111/bdi.12418
dc.identifier.citation Bipolar Disorders. Hoboken, v. 18, n. 5, p. 433-439, 2016.
dc.identifier.issn 1398-5647
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51202
dc.description.abstract Objectives: Accumulating evidence indicates that oxidative stress and neurotrophins have a bidirectional relationship. In this post hoc, exploratory analysis, we investigated the association between plasma brain-derived neurotrophic factor (BDNF) levels and activities of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in individuals with bipolar disorder (BD) and healthy controls. Methods: We measured plasma levels of BDNF and activities of GPx and SOD in individuals with BD (n=59) and healthy controls (n=26). Information related to current and past psychiatric/medical history, as well as to metabolic comorbidities, was also reported. Results: There were negative correlations between BDNF, GPx (r=-.449, P=.001) and GPx/SOD ratio (r=-.503, P<.001), and a positive correlation between BDNF and SOD (r=.254, P=.020). There was a moderating effect of body mass index (BMI) on the association between BDNF and GPx/SOD rate ratio [(RR)=1.002, P=.034] en
dc.description.abstract interactions between impaired glucose metabolism (IGM), GPx (RR=1.016, P=.033), and GPx/SOD ratio (RR=1.026, P=.002) were also observed. These results were significant in models that included age, gender, alcohol, tobacco and medication use. Conclusions: There was a robust and independent correlation between peripheral BDNF and antioxidant enzyme activities in individuals with BD, which was moderated by metabolic comorbidities. These results reinforce the concept that these systems are associated and further extend knowledge of the putative effect of metabolic comorbidities in the pathophysiological substrates of BD. en
dc.format.extent 433-439
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.rights Acesso restrito
dc.subject bipolar disorder en
dc.subject body mass index en
dc.subject brain-derived neurotrophic factor en
dc.subject diabetes en
dc.subject oxidative stress en
dc.title Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Res Grp Behav Neurosci Bipolar Disorder GP TB, Sao Paulo, Brazil
dc.description.affiliation Univ Toronto, Univ Hlth Network, MDPU, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada
dc.description.affiliation Univ Tubingen, Clin Psychiat & Psychotherapy, Dept Psychiat, Tubingen, Germany
dc.description.affiliation Vila Maria Outpatient Clin, Sao Paulo, Brazil
dc.description.affiliation ISCMSP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Res Grp Behav Neurosci Bipolar Disorder GP TB, Sao Paulo, Brazil
dc.identifier.doi 10.1111/bdi.12418
dc.description.source Web of Science
dc.identifier.wos WOS:000388307900005



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