Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet

Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet

Author Chang, Eun Hyuk Google Scholar
Adorjan, Istvan Google Scholar
Mundim, Mayara V. Autor UNIFESP Google Scholar
Sun, Bin Google Scholar
Dizon, Maria L. V. Google Scholar
Szele, Francis G. Google Scholar
Abstract Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.
Keywords adult neurogenesis
stem cells
traumatic brain injury (TBI)
regeneration
proliferation
Language English
Sponsor NIH RO1 NIH/NINDS [R01NS086945-01]
MRC/NNSFC project [MR/M010554/1]
China Scholarship Council
Henry Lester Trust
FAPESP [2012/06810-1, 2014/00927-0]
Grant number NIH/NINDS:R01NS086945-01
MRC/NNSFC project:MR/M010554/1
FAPESP:2012/06810-1
2014/00927-0
Date 2016
Published in Frontiers In Neuroscience. Lausanne, v. 10, p. -, 2016.
ISSN 1662-453X (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3339/fnins.2016.00332
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000381085600001
URI http://repositorio.unifesp.br/handle/11600/51177

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