Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology

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dc.contributor.author Mansur, Rodrigo B. [UNIFESP]
dc.contributor.author Cunha, Graccielle R. [UNIFESP]
dc.contributor.author Asevedo, Elson [UNIFESP]
dc.contributor.author Zugman, Andre [UNIFESP]
dc.contributor.author Zeni-Graiff, Maiara [UNIFESP]
dc.contributor.author Rios, Adiel C. [UNIFESP]
dc.contributor.author Sethi, Sumit [UNIFESP]
dc.contributor.author Maurya, Pawan K. [UNIFESP]
dc.contributor.author Levandowski, Mateus L.
dc.contributor.author Gadelha, Ary [UNIFESP]
dc.contributor.author Pan, Pedro M. [UNIFESP]
dc.contributor.author Stertz, Laura
dc.contributor.author Belangero, Sintia I. [UNIFESP]
dc.contributor.author Anna, Marcia Kauer-Sant'
dc.contributor.author Teixeira, Antonio L.
dc.contributor.author Mari, Jair J. [UNIFESP]
dc.contributor.author Rohde, Luis A.
dc.contributor.author Miguel, Euripedes C.
dc.contributor.author McIntyre, Roger S.
dc.contributor.author Grassi-Oliveira, Rodrigo
dc.contributor.author Bressan, Rodrigo A. [UNIFESP]
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.date.accessioned 2019-07-22T15:46:55Z
dc.date.available 2019-07-22T15:46:55Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1371/journal.pone.0160455
dc.identifier.citation Plos One. San Francisco, v. 11, n. 8, p. -, 2016.
dc.identifier.issn 1932-6203
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51174
dc.description.abstract Background Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004 en
dc.description.abstract 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028 en
dc.description.abstract 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997 en
dc.description.abstract 1.066, p = 0.077). SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED. Conclusions In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems. en
dc.description.sponsorship National Council for Scientific and Technological Development (CNPq)
dc.description.sponsorship Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorship Sao Paulo Research Foundation (FAPESP)
dc.format.extent -
dc.language.iso eng
dc.publisher Public Library Science
dc.rights Acesso aberto
dc.title Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology en
dc.type Artigo
dc.description.affiliation CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliation Univ Toronto, Mood Disorders Psychopharmacol Unit MDPU, Univ Hlth Network, Toronto, ON, Canada
dc.description.affiliation Pontificia Univ Catolica Rio Grande do Sul, Inst Biomed Res, Porto Alegre, RS, Brazil
dc.description.affiliation Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliation Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Ctr Translat Psychiat, Houston, TX 77030 USA
dc.description.affiliation Univ Fed Minas Gerais, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.identifier.file WOS000381368900059.pdf
dc.identifier.doi 10.1371/journal.pone.0160455
dc.description.source Web of Science
dc.identifier.wos WOS:000381368900059



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