Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance

Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance

Author Molin Netto, Barbara Dal Autor UNIFESP Google Scholar
Earthman, Carrie P. Google Scholar
Bettini, Solange Cravo Google Scholar
Grotti Clemente, Ana Paula Autor UNIFESP Google Scholar
Landi Masquio, Deborah Cristina Autor UNIFESP Google Scholar
Farias, Gisele Google Scholar
Boritza, Katia Google Scholar
da Silva, Larissa Gabrielle Google Scholar
von der Heyde, Maria Emilia Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Abstract Introduction Body weight varies depending on the prevailing direction of environmental pressures

however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3 +/- 6.4 to 31.7 +/- 5.7 kg/m(2) (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2 +/- 25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator alpha-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between a-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
Keywords energy regulation
gastric bypass
gastrointestinal hormones
neuropeptides
obesity
Language English
Sponsor Sao Paulo Research Foundation (FAPESP) [2013/04136-4]
CNPq [300654/2013-8 -UNIFESP-EPM]
CAPES [BEX 2262/14-2, 2566/2011]
Grant number FAPESP:2013/04136-4
CNPq:300654/2013-8
CAPES:2262/14-2
2566/2011]
Date 2016
Published in European Journal Of Gastroenterology & Hepatology. Philadelphia, v. 28, n. 9, p. 1050-1055, 2016.
ISSN 0954-691X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1050-1055
Origin http://dx.doi.org/10.1097/MEG.0000000000000665
Access rights Closed access
Type Article
Web of Science ID WOS:000380805300012
URI http://repositorio.unifesp.br/handle/11600/51144

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account