Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report

Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report

Author Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Santos, Camila M. Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Noto, Mariane N. Autor UNIFESP Google Scholar
Pedrini, Mariana Autor UNIFESP Google Scholar
Zeni-Graiff, Maiara Autor UNIFESP Google Scholar
Gouvea, Eduardo S. Google Scholar
Cordeiro, Quirino Google Scholar
Reininghaus, Eva Z. Google Scholar
McIntyre, Roger S. Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p < 0.001) and IGM (p = 0.019) were associated with increased GPx activity, whereas only BD was associated with decreased SOD activity (p = 0.008). We also observed an interaction between BD and IGM on SOD activity (p = 0.017), whereas the difference between BD and controls was only significant in individuals with IGM (p = 0.009). IGM, GPx and SOD activity were independently associated with variables of illness course. Moreover, IGM moderated the association between SOD activity and number of mood episodes (p < 0.001), as a positive correlation between SOD activity and mood episodes was observed only in participants with IGM. In conclusion, BD and IGM are associated with independent and synergistic effects on markers of oxidative stress. The foregoing observations suggest that the heterogeneity observed in previous studies evaluating antioxidant enzymes in BD may be a function of concurrent IGM

and that imbalances in the oxidative system may subserve the association between BD and IGM, as well as its relationship with illness course. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords bipolar disorder
Oxidative stress
Impaired glucose metabolism
Diabetes mellitus
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Grant number FAPESP: 2012/11428-9
Date 2016
Published in Journal Of Psychiatric Research. Oxford, v. 80, p. 38-44, 2016.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 38-44
Origin http://dx.doi.org/10.1016/j.jpsychires.2016.05.014
Access rights Closed access
Type Article
Web of Science ID WOS:000382347100007
URI http://repositorio.unifesp.br/handle/11600/51133

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