Intermittent ethanol binge exposure impairs object recognition but spares contextual and tone fear memory in adolescent rats

Intermittent ethanol binge exposure impairs object recognition but spares contextual and tone fear memory in adolescent rats

Autor Schaaffhausen, Nicole Tatit Von Google Scholar
Oliveira, Fernanda Alves Google Scholar
Carvalho, Thiago Nogueira Autor UNIFESP Google Scholar
Oliveira, Michel Gonçalves Autor UNIFESP Google Scholar
Richtzenhain, Maria Helena Google Scholar
Santos-Junior, Jair Guilherme Autor UNIFESP Google Scholar
Instituição Santa Casa de São Paulo Faculdade de Ciências Médicas
Universidade Federal de São Paulo (UNIFESP)
Resumo Adolescent brain development seems to be important for the maturation of brain structures and behavior. Intermittent binge ethanol drinking is common among adolescents, and this type of drinking can induce brain damage and cognitive deficits. In addition, emotional changes are frequently seen in alcoholics and rodents treated with ethanol. Considering the close relation between emotional arousal and cognitive responses, the present work investigates if intermittent ethanol binge exposure could differentially alter the performance of adolescent rats in aversive and non-aversive motivated tests. Male adolescent rats were submitted to ethanol treatment (2.5 or 5.0 g/Kg, o.a.) at 48-h intervals over postnatal day (PND) 30 to 60. Control animals were exposed to a similar administration protocol with saline administration. At PND61-PND63 animals were submitted to one-trial object recognition or contextual and tone fear conditioning paradigms. Binge ethanol drinking (at both 2.5 and 5.0 g/Kg) did not change freezing response in the contextual and tone fear conditioning. However, all doses impaired recognition rates 24h after training in object recognition test. In addition, despite a diminution of horizontal locomotion in the open field (only for the 5.0 g/Kg dose), no difference was detected regarding time in immobility, time in grooming and number of rearing in this paradigm. The present results show that the cognitive impairment resulting from intermittent binge ethanol exposure has a negative correlation with learning-associated emotional arousal.
Palavra-chave ethanol
binge drinking
adolescent rats
learning and memory
emotional arousal
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2009-06-01
Publicado em Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 2, n. 1, p. 75-81, 2009.
ISSN 1983-3288 (Sherpa/Romeo)
Publicador Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo
Extensão 75-81
Fonte http://dx.doi.org/10.3922/j.psns.2009.1.11
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1983-32882009000100011 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5108

Exibir registro completo




Arquivo

Nome: S1983-32882009000100011.pdf
Tamanho: 735.0KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta