Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Author Piccolomini, Mariana M. Google Scholar
Nicolielo, Mariana Google Scholar
Bonetti, Tatiana C. S. Autor UNIFESP Google Scholar
Motta, Eduardo L. A. Autor UNIFESP Google Scholar
Serafini, Paulo C. Google Scholar
Alegretti, Jose Roberto Google Scholar
Abstract The aneuploidy rates in expanded blastocysts biopsied on days 5 and 6 development were assessed in women undergoing IVF followed by array comparative genomic hybridization. This study included 1171 expanded blastocysts from 465 patients. Among the 465 patients, 215 and 141 underwent embryo biopsy on day 5 and day 6 (46.2% and 30.3%, respectively), and 109 underwent biopsy on both days 5 and 6 (23.4%). The cycles of 206 women were cancelled because only aneuploidy embryos were present (44.3%). The aneuploid embryos were classified according to the type as single, double or complex aneuploidy. No differences were observed in the distributions of these three categories according to the day of the biopsy. The aneuploidy rate was also evaluated according to maternal age, and was found to be higher in older patients

however, no differences in this rate were detected between embryos biopsied on days 5 and 6 according to maternal age. Biopsy was carried out when blastocysts reached the expanded stage. The embryos biopsied on day 6 had a higher rate of aneuploidy (69.9%) than those biopsied on day 5 (61.4%)

however, the euploid embryos transferred had similar chances for successful and healthy gestation. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Keywords array-CGH
embryo aneuploidy
embryo culture
trophectoderm biopsy
Language English
Date 2016
Published in Reproductive Biomedicine Online. Oxford, v. 33, n. 3, p. 398-403, 2016.
ISSN 1472-6483 (Sherpa/Romeo, impact factor)
Publisher Elsevier Sci Ltd
Extent 398-403
Origin http://dx.doi.org/10.1016/j.rbmo.2016.06.005
Access rights Closed access
Type Article
Web of Science ID WOS:000386589100009
URI http://repositorio.unifesp.br/handle/11600/51065

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