Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy

Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy

Author Peres, Fernanda F. Autor UNIFESP Google Scholar
Levin, Raquel Autor UNIFESP Google Scholar
Almeida, Valeria Autor UNIFESP Google Scholar
Zuardi, Antonio W. Google Scholar
Hallak, Jaime E. Google Scholar
Crippa, Jose A. Google Scholar
Abilio, Vanessa C. Autor UNIFESP Google Scholar
Abstract Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder. Recent data point to the participation of the endocannabinoid system in the pathophysiology and pharmacotherapy of schizophrenia. Here, we focus on the effects of cannabinoid drugs on the PPI deficit of animal models of schizophrenia, with greater focus on the SHR (Spontaneously Hypertensive Rats) strain, and on the future prospects resulting from these findings.
Keywords prepulse inhibition of startle reflex
animal models
schizophrenia
cannabidiol
endocannabinoid system
SHR strain
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP
Conselho Nacional do Desenvolvimento Cientifico e Tecnologico-CAPES
Date 2016
Published in Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
ISSN 1663-9812 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fphar.2016.00303
Access rights Closed access
Type Revisão
Web of Science ID WOS:000382714800001
URI http://repositorio.unifesp.br/handle/11600/50972

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