Changes in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitarius

Changes in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitarius

Autor Ogihara, Cristiana Akemi Autor UNIFESP Google Scholar
Schoorlemmer, Gerhardus Hermanus Maria Autor UNIFESP Google Scholar
Colombari, Eduardo Autor UNIFESP Google Scholar
Sato, Monica Akemi Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Faculdade de Medicina do ABC Departamento de Fisiologia
Resumo Ablation of the area postrema/caudal nucleus of the tractus solitarius (NTS) complex increases sodium intake, but the effect of selective lesions of the caudal NTS is not known. We measured depletion-induced sodium intake in rats with electrolytic lesions of the commissural NTS that spared the area postrema. One day after the lesion, rats were depleted of sodium with furosemide (10 mg/kg body weight, sc) and then had access to water and a sodium-deficient diet for 24 h when 1.8% NaCl was offered. Water and saline intakes were measured for 2 h. Saline intake was higher in lesioned than in sham-lesioned rats (mean ± SEM: 20 ± 2 vs 11 ± 3 mL/2 h, P < 0.05, N = 6-7). Saline intake remained elevated in lesioned rats when the tests were repeated 6 and 14 days after the lesion, and water intake in these two tests was increased as well. Water intake seemed to be secondary to saline intake both in lesioned and in sham-lesioned rats. A second group of rats was offered 10% sucrose for 2 h/day before and 2, 7, and 15 days after lesion. Sucrose intake in lesioned rats was higher than in sham-lesioned rats only 7 days after lesioning. A possible explanation for the increased saline intake in rats with commissural NTS lesions could be a reduced gastrointestinal feedback inhibition. The commissural NTS is probably part of a pathway for inhibitory control of sodium intake that also involves the area postrema and the parabrachial nucleus.
Palavra-chave Nucleus of the solitary tract
Sodium appetite
Idioma Inglês
Data de publicação 2009-06-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 6, p. 561-566, 2009.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 561-566
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000266135800002
SciELO S0100-879X2009000600014 (estatísticas na SciELO)
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