Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation

Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation

Author Navarro-Xavier, Roberta Araujo Autor UNIFESP Google Scholar
de Barros, Karina Vieira Autor UNIFESP Google Scholar
de Andrade, Iracema Senna Autor UNIFESP Google Scholar
Palomino, Zaira Autor UNIFESP Google Scholar
Casarini, Dulce Elena Autor UNIFESP Google Scholar
Flor Silveira, Vera Lucia Autor UNIFESP Google Scholar
Abstract Background: The increased prevalence of asthma and allergic diseases in westernized societies has been associated with increased intake of diets rich in n-6 fatty acids (FAs) and poor in n-3 FAs. This study aimed to analyze the prophylactic effects of treatment with a soybean oil-rich diet (rich in n-6) or fish oil (rich in n-3) in an allergic airway inflammation model on lung inflammation score, leukocyte migration, T-helper cell (Th)-2 (interleukin [IL]-4, IL-5) and Th1 (interferon [IFN]-gamma, tumor necrosis factor-alpha) cytokines, lipoxin A4, nitric oxide, bradykinin, and corticosterone levels in bronchoalveolar lavage (BAL) or lungs. Methods: Male Wistar rats fed with soybean oil-or fish oil-rich diet or standard rat chow were sensitized twice with ovalbumin-alumen and challenged twice with ovalbumin aerosol. The BAL and lungs were examined 24 hours later. Results: Both diets, rich in n-6 or n-3 FAs, impaired the allergic lung inflammation and reduced leukocyte migration, eosinophil and neutrophil percentages, and IL-4/IL-5/bradykinin levels in BAL and/or lungs, as well as increased the nitric oxide levels in BAL. The soybean oil-rich diet additionally increased the levels of lipoxin A4 and corticosterone in the lungs. Conclusion: Data presented demonstrated that the n-6 FA-rich diet had protective effect upon allergic airway inflammation and was as anti-inflammatory as the n-3 FA-rich diet, although through different mechanisms, suggesting that both diets could be considered as complementary therapy or a prophylactic alternative for allergic airway inflammation.
Keywords asthma
nitric oxide
n-6 fatty acids
n-3 fatty acids
cytokines
lipoxin A4
bradykininPolyunsaturated Fatty-Acids
Nitric-Oxide Synthesis
Lipoxin A(4)
Up-Regulation
Asthma-Treatment
In-Vivo
Bradykinin
Receptor
Rats
Hyperresponsiveness
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2006/57075-9
CNPq: 302213/2010-4
Date 2016
Published in Journal Of Inflammation Research. Albany, v. 9, p. 79-89, 2016.
ISSN 1178-7031 (Sherpa/Romeo, impact factor)
Publisher Dove Medical Press Ltd
Extent 79-89
Origin http://dx.doi.org/10.2147/JIR.S102221
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000384222600002
URI http://repositorio.unifesp.br/handle/11600/49705

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