Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy

Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy

Author Vale, Thiago Cardoso Google Scholar
Fernandes do Prado, Lucila Bizari Autor UNIFESP Google Scholar
do Prado, Gilmar Fernandes Autor UNIFESP Google Scholar
Povoas Barsottini, Orlando Graziani Autor UNIFESP Google Scholar
Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Abstract Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
Keywords immunotherapy
paraneoplastic cerebellar degeneration
REM sleep
REM-sleep behavior disorderRem-Sleep
Limbic Encephalitis
Antibodies
Ataxia
Language English
Date 2016
Published in Sleep. Westchester, v. 39, n. 1, p. 117-120, 2016.
ISSN 0161-8105 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Sleep Medicine
Extent 117-120
Origin http://dx.doi.org/10.5665/sleep.5330
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000367515700017
URI http://repositorio.unifesp.br/handle/11600/49677

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