Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

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dc.contributor.author Botelho, Marco A.
dc.contributor.author Barros, Gisele
dc.contributor.author Queiroz, Dinalva B.
dc.contributor.author Carvalho, Celso Felicio
dc.contributor.author Gouvea, Julia
dc.contributor.author Patrus, Lia
dc.contributor.author Bannet, Mariane
dc.contributor.author Patrus, Danile
dc.contributor.author Rego, Amalia
dc.contributor.author Silva, Ivaldo [UNIFESP]
dc.contributor.author Campus, Guglielmo
dc.contributor.author Araujo-Filho, Irami
dc.date.accessioned 2019-01-21T10:30:16Z
dc.date.available 2019-01-21T10:30:16Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1002/ptr.5516
dc.identifier.citation Phytotherapy Research. Hoboken, v. 30, n. 1, p. 152-159, 2016.
dc.identifier.issn 0951-418X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49664
dc.description.abstract Lippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern region of Brazil. It is popularly known as Alecrim-pimenta '. Recent studies have shown that some species of Lippia have interesting pharmacological activities. This study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2mg/g on acute phase of ligature-induced periodontitis model [acute periodontal disease (APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement on left molars in maxillae. Animals were treated with TG, immediately after APD induction. Saline-based gel was utilized as negative control and diethylammonium diclofenac gel 10mg/g was used as positive control. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. TG treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared with the saline gel control group (p < 0.05). The TG gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model. Copyright (c) 2015 John Wiley & Sons, Ltd. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship IFCE Edital PRO INFRA
dc.format.extent 152-159
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Phytotherapy Research
dc.rights Acesso restrito
dc.subject Lippia sidoides en
dc.subject periodontitis en
dc.subject Verbenacea en
dc.subject thymol en
dc.subject nanotechnology en
dc.subject Brazilian plantsLigature-Induced Periodontitis en
dc.subject Hormone Replacement Therapy en
dc.subject Alveolar Bone-Resorption en
dc.subject Essential Oil Mouthrinse en
dc.subject Gingivitis en
dc.subject Carvacrol en
dc.subject Mice en
dc.title Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats en
dc.type Artigo
dc.description.affiliation Univ Fed Rio Grande do Norte, Dept Surg, BR-59072970 Natal, RN, Brazil
dc.description.affiliation Univ Potiguar, Post Graduat Program Biotechnol, Natal, RN, Brazil
dc.description.affiliation Univ Anhembi Morumbi, Sch Hlth, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Gynaecol, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Sassari, Sch Dent, Dept Surg Microsurg & Med Sci, I-07100 Sassari, Italy
dc.description.affiliationUnifesp Departament of Gynecology, Federal University of São PauloSao Paulo, SP, Brazil
dc.description.sponsorshipID CNPq; 310483/2012-3
dc.identifier.doi 10.1002/ptr.5516
dc.description.source Web of Science
dc.identifier.wos WOS:000367919300021



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