Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

Author Botelho, Marco A. Google Scholar
Barros, Gisele Google Scholar
Queiroz, Dinalva B. Google Scholar
Carvalho, Celso Felicio Google Scholar
Gouvea, Julia Google Scholar
Patrus, Lia Google Scholar
Bannet, Mariane Google Scholar
Patrus, Danile Google Scholar
Rego, Amalia Google Scholar
Silva, Ivaldo Autor UNIFESP Google Scholar
Campus, Guglielmo Google Scholar
Araujo-Filho, Irami Google Scholar
Abstract Lippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern region of Brazil. It is popularly known as Alecrim-pimenta '. Recent studies have shown that some species of Lippia have interesting pharmacological activities. This study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2mg/g on acute phase of ligature-induced periodontitis model [acute periodontal disease (APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement on left molars in maxillae. Animals were treated with TG, immediately after APD induction. Saline-based gel was utilized as negative control and diethylammonium diclofenac gel 10mg/g was used as positive control. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. TG treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared with the saline gel control group (p < 0.05). The TG gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model. Copyright (c) 2015 John Wiley & Sons, Ltd.
Keywords Lippia sidoides
periodontitis
Verbenacea
thymol
nanotechnology
Brazilian plantsLigature-Induced Periodontitis
Hormone Replacement Therapy
Alveolar Bone-Resorption
Essential Oil Mouthrinse
Gingivitis
Carvacrol
Mice
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
IFCE Edital PRO INFRA
Grant number CNPq; 310483/2012-3
Date 2016
Published in Phytotherapy Research. Hoboken, v. 30, n. 1, p. 152-159, 2016.
ISSN 0951-418X (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 152-159
Origin http://dx.doi.org/10.1002/ptr.5516
Access rights Closed access
Type Article
Web of Science ID WOS:000367919300021
URI http://repositorio.unifesp.br/handle/11600/49664

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