Methyl-CpG-Binding Protein (MBD) Family: Epigenomic Read-Outs Functions and Roles in Tumorigenesis and Psychiatric Diseases

Show simple item record

dc.contributor.author Gigek, Carolina Oliveira [UNIFESP]
dc.contributor.author Chen, Elizabeth Suchi [UNIFESP]
dc.contributor.author Smith, Marilia Arruda Cardoso [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:15Z
dc.date.available 2019-01-21T10:30:15Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1002/jcb.25281
dc.identifier.citation Journal Of Cellular Biochemistry. Hoboken, v. 117, n. 1, p. 29-38, 2016.
dc.identifier.issn 0730-2312
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49660
dc.description.abstract Epigenetics is the study of the heritable changes on gene expression that are responsible for the regulation of development and that have an impact on several diseases. However, it is of equal importance to understand how epigenetic machinery works. DNA methylation is the most studied epigenetic mark and is generally associated with the regulation of gene expression through the repression of promoter activity and by affecting genome stability. Therefore, the ability of the cell to interpret correct methylation marks and/or the correct interpretation of methylation plays a role in many diseases. The major family of proteins that bind methylated DNA is the methyl-CpG binding domain proteins, or the MBDs. Here, we discuss the structure that makes these proteins a family, the main functions and interactions of all protein family members and their role in human disease such as psychiatric disorders and cancer. (C) 2015 Wiley Periodicals, Inc. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 29-38
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal Of Cellular Biochemistry
dc.rights Acesso restrito
dc.subject Methyl-Cpg Binding Protein en
dc.subject Epigenetics en
dc.subject Dna Methylation en
dc.subject Cancer en
dc.subject Autism en
dc.subject Schizophrenia2q23.1 Microdeletion Syndrome en
dc.subject Histone Deacetylase Complex en
dc.subject Epigenetic Down-Regulation en
dc.subject Colon-Cancer Cells en
dc.subject Stem-Cells en
dc.subject Dna Methylation en
dc.subject Neurodevelopmental Disorders en
dc.subject Glu346lys Polymorphism en
dc.subject Chinese Population en
dc.subject Autistic Patients en
dc.title Methyl-CpG-Binding Protein (MBD) Family: Epigenomic Read-Outs Functions and Roles in Tumorigenesis and Psychiatric Diseases en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, UNIFESP, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Cirurgia, Disciplina Gastroenterol, UNIFESP, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Cirurgia, Disciplina Gastroenterol
dc.description.affiliationUnifesp Rua Botucatu 740,Edificio Leitao Cunha,1 Andar, BR-04023900 Sao Paulo, Brazil.
dc.identifier.doi 10.1002/jcb.25281
dc.description.source Web of Science
dc.identifier.wos WOS:000368229800003



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account