Alkaloids from croton echinocarpus baill.: Anti-hiv potential

Alkaloids from croton echinocarpus baill.: Anti-hiv potential

Author Ravanelli, N. Google Scholar
Santos, Kátia P. Google Scholar
Motta, Lucimar Barbosa da Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Furlan, Cláudia Maria Google Scholar
Abstract Croton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.
Keywords Norisoboldine
Corydine
Croton
Anti-Hiv ActivityDragons Blood
Molecular Phylogenetics
Euphorbiaceae
Extracts
Identification
Constituents
Urucurana
Plants
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2012/10079-0]
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Grant number FAPESP: 2012/10079-0
Date 2016
Published in South African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016.
ISSN 0254-6299 (Sherpa/Romeo, impact factor)
Publisher Elsevier science bv
Extent 153-156
Origin https://doi.org/10.1016/j.sajb.2015.06.011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368959100021
URI http://repositorio.unifesp.br/handle/11600/49647

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