Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (pihn) method

Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (pihn) method

Author Araya-Sibaja, Andrea Mariela Google Scholar
Soldi, Valdir Google Scholar
Maduro de Campos, Carlos Eduardo Google Scholar
Cardoso, Simone Goncalves Google Scholar
Cuffini, Silvia Lucia Autor UNIFESP Google Scholar
Abstract The selective crystallization of progesterone polymorphs prepared by Polymer-Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5,10 and 40 mg mL(-1) solutions in chloroform at room temperature by solvent evaporation. The samples were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy. Form 2 was obtained from 0.5 mg mL(-1) solution in almost all polymers. A mixture of both poly morphs crystallized from the three concentrations on gelatine

from 10 and 40mg mL(-1) on PVA and HPMC and, from 10 mg mL(-1) solutions on NBR. Form 2 crystallized on HPMC was stable for three months under ambient stress conditions (40 degrees C and 75% RH). These results are good evidence that the tailoring of new formulations and devices with progesterone the metastable and more soluble form 2 is possible.
Keywords Crystal Growth
Progesterone Polymorphs
Polymer Induced Heteronucleation
Stability StudyDiscovery
Transformation
Heteronuclei
Solubility
Progestins
Selection
Language English
Sponsor CNPq
CAPES
FAPESC
CLAF
CONICET
Laboratorio de Difracao de Raio-X (LDRX)
Laboratorio Central de Microscopia Eletronica (LCME) at UFSC
CONICET, Argentina
Consejo Superior de Investigaciones Cientificas (CSIC) of Spain
Fundacion Sauberan
Date 2016
Published in Crystal Research And Technology. Weinheim, v. 51, n. 1, p. 49-57, 2016.
ISSN 0232-1300 (Sherpa/Romeo, impact factor)
Publisher Wiley-v c h verlag gmbh
Extent 49-57
Origin https://doi.org/10.1002/crat.201500145
Access rights Closed access
Type Article
Web of Science ID WOS:000368703100007
URI http://repositorio.unifesp.br/handle/11600/49640

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