Fosi is a new integron-associated gene cassette encoding reduced susceptibility to fosfomycin

Fosi is a new integron-associated gene cassette encoding reduced susceptibility to fosfomycin

Author Pelegrino, Karla de Oliveira Google Scholar
Campos, Juliana Coutinho Google Scholar
Ferreira Sampaio, Suely Carlos Google Scholar
Lezirovitz, Karina Google Scholar
Seco, Bruna Mara Google Scholar
Pereira, Mayne de Oliveira Google Scholar
da Costa Rocha, Darlan Augusto Google Scholar
Jove, Thomas Google Scholar
Nicodemo, Antonio Carlos Google Scholar
Mello Sampaio, Jorge Luiz Google Scholar
Abstract In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 mu g/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 mu g/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.
Keywords Urinary-Tract-Infections
Escherichia-Coli
Mycobacterium-Tuberculosis
Klebsiella-Pneumoniae
Resistance Gene
Outcomes
Epidemiology
Mechanism
Plasmids
Bacteria
Language English
Sponsor Sao Paulo Research Foundation (FAPESP) [2010/00807-3]
Grant number FAPESP: 2010/00807-3
Date 2016
Published in Antimicrobial Agents And Chemotherapy. Washington, v. 60, n. 1, p. 686-688, 2016.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer soc microbiology
Extent 686-688
Origin http://dx.doi.org/10.1128/AAC.02437-15
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000369154600094
URI http://repositorio.unifesp.br/handle/11600/49623

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