Minimizing the uncertainties regarding the effects of delaying radiotherapy for glioblastoma: a systematic review and meta-analysis

Minimizing the uncertainties regarding the effects of delaying radiotherapy for glioblastoma: a systematic review and meta-analysis

Author Loureiro, Luiz Victor Maia Google Scholar
Victor, Elivane da Silva Google Scholar
Callegaro-Filho, Donato Google Scholar
Koch, Ludmila de Oliveira Google Scholar
Pontes, Luciola de Barros Google Scholar
Weltman, Eduardo Google Scholar
Rother, Edna Terezinha Google Scholar
Fleury Malheiros, Suzana Maria Google Scholar
Abstract Background and purpose: Previous studies have provided no clear conclusions regarding the effects of delaying radiotherapy (RT) in GBM patients. We present a systematic review and meta-analysis to address the effect of delayed RT on the overall survival (OS) of GBM patients. Methods: A systematic search retrieved 19 retrospective studies published between 1975 and 2014 reporting on the waiting time (WT) to RT for GBM patients. The meta-analysis was performed by converting WT to RT studies intervals into a regression coefficient (beta) and standard error expressing the effect size on OS per week of delay. Results: Data required to calculate the effect size on OS per week of delay were available for 12 studies (5212 patients). A non-adjusted model and a meta-regression model based on well-recognized prognostic factors were performed. No association between WT to RT, per week of delay, and OS was found (HR = 0.98

95% CI 0.90-1.08

p = 0.70). The meta-regression adjusted for prognostic factors weighted by the inverse-variance (1/SE2) showed no clear evidence of the effect of WT to RT, per week of delay, on OS. Conclusions: This meta-analysis, despite limitations, provided no evidence of a true effect on OS by delaying RT in GBM patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Keywords Glioblastoma
Radiotherapy
Waiting Time
Delay
Prognosis
SurvivalNewly-Diagnosed Glioblastoma
High-Grade Gliomas
Waiting-Times
Postoperative Radiotherapy
Radiation-Therapy
Tumor-Control
Multiforme Survival
Secondary Analysis
Prognostic-Factors
Malignant Glioma
Language English
Sponsor Institute UNIEMP, Instituto Israelita de Ensino e Pesquisa Albert Einstein
Grant number This work was supported by grants from Institute UNIEMP, Instituto Israelita de Ensino e Pesquisa Albert Einstein.
Date 2016
Published in Radiotherapy And Oncology. Clare, v. 118, n. 1, p. 1-8, 2016.
ISSN 0167-8140 (Sherpa/Romeo, impact factor)
Publisher Elsevier ireland ltd
Extent 1-8
Origin https://doi.org/10.1016/j.radonc.2015.11.021
Access rights Closed access
Type Revisão
Web of Science ID WOS:000371551100001
URI http://repositorio.unifesp.br/handle/11600/49595

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