Thyroid-specific genes expression uncovered age-related differences in pediatric thyroid carcinomas

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dc.contributor.author Cordioli, Maria Isabel Cunha Vieira [UNIFESP]
dc.contributor.author Moraes, Lais [UNIFESP]
dc.contributor.author Alves, Maria Teresa de Seixas [UNIFESP]
dc.contributor.author Delcelo, Rosana [UNIFESP]
dc.contributor.author Monte, Osmar
dc.contributor.author Longui, Carlos Alberto
dc.contributor.author Cury, Adriano Namo
dc.contributor.author Cerutti, Janete Maria [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:06Z
dc.date.available 2019-01-21T10:30:06Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1155/2016/1956740
dc.identifier.citation International Journal Of Endocrinology. New York, 2016.
dc.identifier.issn 1687-8337
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49577
dc.description.abstract Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (>= 10-18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P < 0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified. en
dc.description.sponsorship Sao Paulo State Research Foundation (FAPESP) [2012/02902-9, 2013/03867-5]
dc.description.sponsorship Brazilian Research Council (CNPq) [470441/2013-5]
dc.language.iso eng
dc.publisher Hindawi publishing corp
dc.relation.ispartof International Journal Of Endocrinology
dc.rights Acesso aberto
dc.subject Sodium-Iodide Symporter en
dc.subject Young-Adults en
dc.subject Cancer en
dc.subject Children en
dc.subject Adolescents en
dc.subject Childhood en
dc.subject Radioiodine en
dc.subject Metabolism en
dc.subject Recurrence en
dc.subject Experience en
dc.title Thyroid-specific genes expression uncovered age-related differences in pediatric thyroid carcinomas en
dc.type Artigo
dc.description.affiliation Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 11 Andar, 04039-032 São Paulo, SP, Brazil
dc.description.affiliation Pediatric Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, Brazil
dc.description.affiliation Thyroid Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, Brazil
dc.description.affiliation Molecular Medicine Laboratory, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, Brazil
dc.description.affiliation Division of Endocrinology, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 11 Andar, 04039-032 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Pediatric Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Thyroid Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2012/02902-9
dc.description.sponsorshipID FAPESP: 2013/03867-5
dc.description.sponsorshipID CNPq: 470441/2013-5
dc.identifier.file WOS000372238800001.pdf
dc.identifier.doi 10.1155/2016/1956740
dc.description.source Web of Science
dc.identifier.wos WOS:000372238800001



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