Thyroid-specific genes expression uncovered age-related differences in pediatric thyroid carcinomas

Thyroid-specific genes expression uncovered age-related differences in pediatric thyroid carcinomas

Author Cordioli, Maria Isabel Cunha Vieira Autor UNIFESP Google Scholar
Moraes, Lais Autor UNIFESP Google Scholar
Alves, Maria Teresa de Seixas Autor UNIFESP Google Scholar
Delcelo, Rosana Autor UNIFESP Google Scholar
Monte, Osmar Google Scholar
Longui, Carlos Alberto Google Scholar
Cury, Adriano Namo Google Scholar
Cerutti, Janete Maria Autor UNIFESP Google Scholar
Abstract Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (>= 10-18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P < 0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified.
Keywords Sodium-Iodide Symporter
Young-Adults
Cancer
Children
Adolescents
Childhood
Radioiodine
Metabolism
Recurrence
Experience
Language English
Sponsor Sao Paulo State Research Foundation (FAPESP) [2012/02902-9, 2013/03867-5]
Brazilian Research Council (CNPq) [470441/2013-5]
Grant number FAPESP: 2012/02902-9
FAPESP: 2013/03867-5
CNPq: 470441/2013-5
Date 2016
Published in International Journal Of Endocrinology. New York, 2016.
ISSN 1687-8337 (Sherpa/Romeo, impact factor)
Publisher Hindawi publishing corp
Origin http://dx.doi.org/10.1155/2016/1956740
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000372238800001
URI http://repositorio.unifesp.br/handle/11600/49577

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