Brazilian data of renal cell carcinoma in a public university hospital

Brazilian data of renal cell carcinoma in a public university hospital

Author Aguiar Junior, Pedro Autor UNIFESP Google Scholar
Padua, Tiago Costa Autor UNIFESP Google Scholar
Guimaraes, Daiane Pereira Autor UNIFESP Google Scholar
Abstract Purpose: Among renal malignancies, renal cell carcinoma (RCC) accounts for 85% of cases. Stage is a relevant prognostic factor

5-year survival ranges from 81% to 8% according to the stage of disease. The treatment is based on surgery and molecularly targeted therapy has emerged as a choice for metastatic disease. Materials and Methods: Retrospective study by reviewing the medical records of patients with RCC treated in the last 10 years at UNIFESP. The primary end point of this trial was to evaluate the overall survival (OS) of the patients. The secondary end point was to evaluate the progression-free survival (PFS) after nephrectomy. Results: 118 patients with RCC were included. The mean age was 58.3 years, 61.9% men

nephrectomy was performed in 90.7%, clear cell was the histology in 85.6%, 44 patients were classified as stage IV at diagnosis. Among these, 34 had already distant metastasis. 29 patients were treated with sunitinib. The median OS among all patients was 55.8 months. The median PFS after nephrectomy was 79.1 months. Sarcomatoid differentiation HR29.74 (95% CI, 4.31-205.26), clinical stage IV HR1.94 (95% CI, 1.37-2.75) and nephrectomy HR0.32 (95% CI, 0.15-0.67) were OS prognostic factors. Sunitinib had clinical activity. Conclusions: Patients treated in our hospital achieved median OS compatible with literature. Nevertheless, this study has shown a high number of patients with advanced disease. For patients with advanced disease, treatment with sunitinib achieved median OS of 28.7 months, consistent with the literature.
Keywords Renal Carcinoma
Nephrectomy
Sunitinib
SurvivalTherapy
Impact
Sunitinib
Survival
Language English
Date 2016
Published in International Braz J Urol. Rio de janeiro, v. 42, n. 1, p. 29-36, 2016.
ISSN 1677-5538 (Sherpa/Romeo, impact factor)
Publisher Brazilian soc urol
Extent 29-36
Origin http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.0452
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000372333400007
SciELO ID S1677-55382016000100029 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/49573

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