Serum cytokine responses over the entire clinical-immunological spectrum of human leishmania (l.) infantum chagasi infection

Serum cytokine responses over the entire clinical-immunological spectrum of human leishmania (l.) infantum chagasi infection

Author Ramos, Patricia Karla Google Scholar
Carvalho, Karina Inacio Google Scholar
Rosa, Daniela Santoro Autor UNIFESP Google Scholar
Rodrigues, Ana Paula Google Scholar
Lima, Luciana Vieira Google Scholar
Campos, Marliane Batista Google Scholar
Gomes, Claudia Maria C. Google Scholar
Laurenti, Marcia Dalastra Google Scholar
Corbett, Carlos Eduardo Google Scholar
Silveira, Fernando Tobias Google Scholar
Abstract The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi infection in Amazonian Brazil was recently reviewed based on clinical, DTH, and IFAT (IgG) evaluations that identified five profiles: three asymptomatic (asymptomatic infection, AI

subclinical resistant infection, SRI

and indeterminate initial infection, III) and two symptomatic (symptomatic infection, SI

American visceral leishmaniasis, AVL

and subclinical oligosymptomatic infection, SOI). TNF-alpha, IL-4, IL-6, and IL-10 serum cytokines were analyzed using multiplexed Cytometric Bead Array in 161 samples from endemic areas in the Brazilian Amazon: SI [AVL] (21 cases), III (49), SRI (19), SOI (12), AI (36), and a control group [CG] (24). The highest IL-6 serumlevels were observed in the SI profile (AVL)

higher IL-10 serum levels were observed in SI than in SOI or CG and in AI and III than in SOI

higher TNF-alpha serum levels were seen in SI than in CG. Positive correlations were found between IL-6 and IL-10 serum levels in the SI and III profiles and between IL-6 and TNF-alpha and between IL-4 and TNF-alpha in the III profile. These results provide strong evidence for associating IL-6 and IL-10 with the immunopathogenesis of AVL and help clarify the role of these cytokines in the infection spectrum.
Keywords Human Visceral Leishmaniasis
Immunity
Il-6
Differentiation
Inflammation
Disease
Profile
Gamma
Language English
Sponsor Instituto Evandro Chagas (Secretaria de Vigilancia em Saude, Ministerio da Saude, Brazil)
Nucleo de Medicina Tropical (Universidade Federal do Para, Brazil)
Laboratorio de Investigacao Medica (LIM)-50 (Hospital de Clinicas (HC)-Faculdade de Medicina (FM)-Universidade de Sao Paulo (USP), Brazil)
Sao Paulo Research Foundation (FAPESP) [2006/56319-1]
Grant number FAPESP: 2006/56319-1
Date 2016
Published in Biomed Research International. London, 2016.
ISSN 2314-6133 (Sherpa/Romeo, impact factor)
Publisher Hindawi ltd
Origin http://dx.doi.org/10.1155/2016/6937980
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000372601100001
URI http://repositorio.unifesp.br/handle/11600/49569

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