Poly(3-hydroxybutyrate-co-valerate)/poly(3-thiophene ethyl acetate) blends as a electroactive biomaterial substrate for tissue engineering application

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dc.contributor.author Recco, M. S. [UNIFESP]
dc.contributor.author Floriano, A. C. [UNIFESP]
dc.contributor.author Tada, D. B. [UNIFESP]
dc.contributor.author Lemes, A. P. [UNIFESP]
dc.contributor.author Lang, R. [UNIFESP]
dc.contributor.author Cristovan, F. H. [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:05Z
dc.date.available 2019-01-21T10:30:05Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1039/c5ra26747a
dc.identifier.citation Rsc Advances. Cambridge, v. 6, n. 30, p. 25330-25338, 2016.
dc.identifier.issn 2046-2069
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49566
dc.description.abstract Polyblends of an electroactive biomaterial consisting of a biodegradable polyester - PHBV and a carboxylate polythiophene derivative, the poly(3-thiophene ethyl acetate) - PTAcEt have been prepared and applied as a substrate for tissue engineering. The biodegradable polymer was used as a matrix for polythiophene. Thermal, electrical, optical and morphological properties as well as viability and cell adhesion (in vitro assays) were investigated. Blend films exhibited high flexibility, resistance to handling and a semiconducting character, since they preserved the individual properties of each polymer. Besides, the incorporation of PTAcEt (up to 12%) has led to improvements in the thermal stability and in the crystallinity degree of the bioactive matrix. Qualitative morphological analysis showed irregular and porous surfaces en
dc.description.abstract important features for growth and cell adhesion. Viability assays indicated that the polyblends promoted superior cell proliferation after 72 h exposure to mammalian cells when compared to a pure PHBV matrix. Therefore, PTAcEt showed low cytotoxicity allowing cell growth. The adhesion study revealed that the cells were able to adhere to the surface and proliferate inside the cavities of the substrate. The results indicate that the 88 : 12% (PHBV : PTAcEt) blend is a promising candidate for use as scaffold in the biomedical area. en
dc.description.sponsorship CNPq
dc.description.sponsorship FAPESP
dc.description.sponsorship FINEP
dc.format.extent 25330-25338
dc.language.iso eng
dc.publisher Royal soc chemistry
dc.relation.ispartof Rsc Advances
dc.rights Acesso restrito
dc.subject Conductive Polymers en
dc.subject Cellular Adhesion en
dc.subject Polythiophene en
dc.subject Scaffolds en
dc.subject Composite en
dc.subject Bone en
dc.subject Proliferation en
dc.subject Growth en
dc.subject Cells en
dc.subject Differentiation en
dc.title Poly(3-hydroxybutyrate-co-valerate)/poly(3-thiophene ethyl acetate) blends as a electroactive biomaterial substrate for tissue engineering application en
dc.type Artigo
dc.description.affiliation Institute of Science and Technology, Universidade Federal de São Paulo – UNIFESP, São José dos Campos, Brazil
dc.description.affiliationUnifesp Institute of Science and Technology, Universidade Federal de São Paulo – UNIFESP, São José dos Campos, Brazil
dc.identifier.doi 10.1039/c5ra26747a
dc.description.source Web of Science
dc.identifier.wos WOS:000372252700061



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