The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats

The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats

Author Lodi, Karina Bortolin Google Scholar
Pereira da Silva Marchini, Adriana Mathias Google Scholar
do Espirito Santo, Ana Maria Autor UNIFESP Google Scholar
Rode, Sigmar de Mello Google Scholar
Marchini, Leonardo Google Scholar
da Rocha, Rosilene Fernandes Google Scholar
Abstract Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female andmaleWistar rats (n = 108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (mu EDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones.
Keywords Alveolar Bone Crest
Estrogen Deficiency
Trabecular Bone
Cortical Bone
Body-Weight
Phosphorus
Fractures
Calcium
Women
Osteoporosis
Language English
Sponsor National Council for Scientific and Technological Development (CNPq-Brazil)
Brazilian governmental research agency, National Council for Scientific and Technological Development (CNPq-Brazil)
Date 2016
Published in International Journal Of Endocrinology. New York, 2016.
ISSN 1687-8337 (Sherpa/Romeo, impact factor)
Publisher Hindawi publishing corp
Origin http://dx.doi.org/10.1155/2016/3797139
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000373141900001
URI http://repositorio.unifesp.br/handle/11600/49561

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