Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women

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dc.contributor.author Rodrigues, L. C. [UNIFESP]
dc.contributor.author de Gois Speck, N. M. [UNIFESP]
dc.contributor.author de Azevedo Focchi, G. R. [UNIFESP]
dc.contributor.author Schimidt, M. A. [UNIFESP]
dc.contributor.author Marques, R. M. [UNIFESP]
dc.contributor.author Lascasas Ribalta, J. C. [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:04Z
dc.date.available 2019-01-21T10:30:04Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.4238/gmr.15017220
dc.identifier.citation Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017220, 2016.
dc.identifier.issn 1676-5680
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49554
dc.description.abstract The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women. en
dc.format.extent UNSP gmr.15017220
dc.language.iso eng
dc.publisher Funpec-editora
dc.relation.ispartof Genetics And Molecular Research
dc.rights Acesso aberto
dc.subject Human Immunodeficiency Virus en
dc.subject E6 Oncoprotein en
dc.subject E7 Oncoprotein en
dc.subject Human Papillomavirus 16/18 en
dc.subject High-Grade Squamous Intraepithelial LesionsHuman-Papillomavirus en
dc.subject Tissue Microarrays en
dc.subject Infection en
dc.subject Dysplasia en
dc.subject Neoplasia en
dc.subject Risk en
dc.title Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women en
dc.type Artigo
dc.description.affiliation Núcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliation Departamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliation Disciplina de Oncologia Ginecológica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifesp Núcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifesp Departamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifesp Disciplina de Oncologia Ginecológica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.identifier.doi 10.4238/gmr.15017220
dc.description.source Web of Science
dc.identifier.wos WOS:000373880200024



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