Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women

Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women

Author Rodrigues, L. C. Autor UNIFESP Google Scholar
de Gois Speck, N. M. Autor UNIFESP Google Scholar
de Azevedo Focchi, G. R. Autor UNIFESP Google Scholar
Schimidt, M. A. Autor UNIFESP Google Scholar
Marques, R. M. Autor UNIFESP Google Scholar
Lascasas Ribalta, J. C. Autor UNIFESP Google Scholar
Abstract The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women.
Keywords Human Immunodeficiency Virus
E6 Oncoprotein
E7 Oncoprotein
Human Papillomavirus 16/18
High-Grade Squamous Intraepithelial LesionsHuman-Papillomavirus
Tissue Microarrays
Infection
Dysplasia
Neoplasia
Risk
Language English
Date 2016
Published in Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017220, 2016.
ISSN 1676-5680 (Sherpa/Romeo, impact factor)
Publisher Funpec-editora
Extent UNSP gmr.15017220
Origin http://dx.doi.org/10.4238/gmr.15017220
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000373880200024
URI http://repositorio.unifesp.br/handle/11600/49554

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