Genetic variability of cyp3a4 in a heterogeneous brazilian population from maranhao

Genetic variability of cyp3a4 in a heterogeneous brazilian population from maranhao

Author Moutinho Monteiro, S. C. Google Scholar
de Sousa, I. H. Google Scholar
Pereira Belfort, I. K. Google Scholar
Nunes, J. D. Google Scholar
Sousa Penha, B. A. Google Scholar
dos Santos, M. Google Scholar
Drumond Louro, I. Google Scholar
Guerreiro da Silva, I. D. C. Autor UNIFESP Google Scholar
Abstract Inter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with Native American, European, and African ancestries, and is therefore considered as one of the most intermixed populations in the world. A thorough knowledge of the genetic frequencies of CYP3A4 allelic variants is useful for the establishment of better pharmacological therapies

therefore, the aim of this study was to describe the polymorphic frequencies for CYP3A4 -392A>G (rs2740574) in a sample population from Maranhao, Brazil. Our results showed that 75.1, 21.9, and 3.0% of the individuals expressed the -392AA, -392AG, and -392GG genotypes, respectively. The -392A and -392G alleles were observed in 86.1 and 13.9% of the population, respectively. Our results reiterate the need for a better understanding of the variations in the genotype and allele frequencies of CYP3A4 -392A>G polymorphisms in various Brazilian regions, in order to elucidate the variability in drug response.
Keywords Cyp3a4(Star)1b
Polymorphism
Genetic Variability
Drug Metabolism
PharmacogeneticsDrug-Metabolism
Variant
Language English
Sponsor CAPES
Date 2016
Published in Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017275, 2016.
ISSN 1676-5680 (Sherpa/Romeo, impact factor)
Publisher Funpec-editora
Extent UNSP gmr.15017275
Origin http://dx.doi.org/10.4238/gmr.15017275
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000373880200030
URI http://repositorio.unifesp.br/handle/11600/49553

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