Expression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or less

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dc.contributor.author Casagrande, D. C. [UNIFESP]
dc.contributor.author Ribalta, J. C. L. [UNIFESP]
dc.contributor.author Leite, K. D. P. F. [UNIFESP]
dc.contributor.author Schimidt, M. [UNIFESP]
dc.contributor.author Speck, N. M. D. G. [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:03Z
dc.date.available 2019-01-21T10:30:03Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.4238/gmr.15017916
dc.identifier.citation Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017916, 2016.
dc.identifier.issn 1676-5680
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49552
dc.description.abstract We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. Negative results of mRNA expression were in accordance with negative cytologies. In positive cases, the infection by a single HPV type was most common, with type 16 being most prevalent. The expression of mRNA was most prevalent in ASC-US and LSIL cytologies, compared with the negative cytology. The infection by a HPV type was more frequent in cases of positive expression, with HPV type 16 being found most frequently. Patients with LSIL cytologies had a higher percentage of multiple infections. en
dc.description.sponsorship Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent UNSP gmr.15017916
dc.language.iso eng
dc.publisher Funpec-editora
dc.relation.ispartof Genetics And Molecular Research
dc.rights Acesso aberto
dc.subject E6/E7 Mrna en
dc.subject Human Papillomavirus en
dc.subject Negative Cytology en
dc.subject Asc-Us Cytology en
dc.subject Lsil CytologyPretect Hpv-Proofer en
dc.subject Dna-Positive Women en
dc.subject Cervical-Cancer en
dc.subject Genotype Distribution en
dc.subject Natural-History en
dc.subject Young-Women en
dc.subject Follow-Up en
dc.subject Neoplasia en
dc.subject Risk en
dc.subject Persistence en
dc.title Expression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or less en
dc.type Artigo
dc.description.affiliation Núcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Escola Paulista de Medicina, São Paulo, SP, Brasil
dc.description.affiliation Departamento de Patologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliation Laboratório Salomão & Zoppi Diagnósticos, São Paulo, SP, Brasil
dc.description.affiliationUnifesp Núcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Escola Paulista de Medicina, São Paulo, SP, Brasil
dc.description.affiliationUnifesp Departamento de Patologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.identifier.doi 10.4238/gmr.15017916
dc.description.source Web of Science
dc.identifier.wos WOS:000373880400085



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