Expression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or less

Expression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or less

Author Casagrande, D. C. Autor UNIFESP Google Scholar
Ribalta, J. C. L. Autor UNIFESP Google Scholar
Leite, K. D. P. F. Autor UNIFESP Google Scholar
Schimidt, M. Autor UNIFESP Google Scholar
Speck, N. M. D. G. Autor UNIFESP Google Scholar
Abstract We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. Negative results of mRNA expression were in accordance with negative cytologies. In positive cases, the infection by a single HPV type was most common, with type 16 being most prevalent. The expression of mRNA was most prevalent in ASC-US and LSIL cytologies, compared with the negative cytology. The infection by a HPV type was more frequent in cases of positive expression, with HPV type 16 being found most frequently. Patients with LSIL cytologies had a higher percentage of multiple infections.
Keywords E6/E7 Mrna
Human Papillomavirus
Negative Cytology
Asc-Us Cytology
Lsil CytologyPretect Hpv-Proofer
Dna-Positive Women
Cervical-Cancer
Genotype Distribution
Natural-History
Young-Women
Follow-Up
Neoplasia
Risk
Persistence
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Date 2016
Published in Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017916, 2016.
ISSN 1676-5680 (Sherpa/Romeo, impact factor)
Publisher Funpec-editora
Extent UNSP gmr.15017916
Origin http://dx.doi.org/10.4238/gmr.15017916
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000373880400085
URI http://repositorio.unifesp.br/handle/11600/49552

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