Igf-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea

Igf-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea

Author Izumi, Suelem Autor UNIFESP Google Scholar
Ribeiro-Filho, Fernando F. Google Scholar
Carneiro, Glaucia Autor UNIFESP Google Scholar
Togeiro, Sania M. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Zanella, Maria T. Autor UNIFESP Google Scholar
Abstract Study Objectives: This study examined insulin-like growth factor-1 (IGF-1) production and its association with the metabolic syndrome (MS) in men with obstructive sleep apnea (OSA). Methods: In total, 47 overweight and obese men who had been referred for suspected OSA underwent polysomnography and were classified based on the apnea-hypopnea index (AHI) into three groups: no OSA, < 5 events/h (n = 11)

mild OSA, >= 5 to < 15 events/h (n = 8)

and moderate-severe OSA, >= 15 events/h (n = 28). The assessment of the somatotropic axis function included IGF-1 measurement. MS was diagnosed according to the National Cholesterol Education Program guidelines. Results: IGF-1 level in the moderate-severe OSA group was lower than in the no-OSA group (156.8 +/- 54.3 mu g/L versus 225.5 +/- 80.5 mu g/L

p = 0.013). IGF-1 level was negatively correlated with body mass index, waist circumference (WC), AHI, and sleep duration with oxygen (O-2) saturation < 90% and positively correlated with the average and minimum O-2 saturation (p = 0.027). In a multivariable linear regression, considering WC and minimum O-2 saturation as independent variables, only the minimum O-2 saturation was a predictor of low IGF-1 levels. The proportions of patients with MS were different between the three groups (18.2% in no OSA

25% in mild OSA, and 57.1% in moderate-severe OSA

p = 0.047). Furthermore, in the lowest tertile of IGF-1 value, 66.7% of patients were affected by MS (p = 0.049). Hemoglobin (Hb)A1c correlated negatively with the minimum O-2 saturation and IGF-1 levels. However, in multivariable linear regression only IGF-1 levels were a predictor of HbA1c levels. Conclusion: The occurrence of OSA is associated with a reduction in IGF-1 levels. IGF-1 alterations in OSA also seem to be associated with a higher prevalence of MS.
Keywords Gh/Igf-1 Axis
Insulin-Like Growth Factor-1
Metabolic Syndrome
Obstructive Sleep ApneaGrowth-Factor-I
Onset Gh Deficiency
Hypopituitary Patients
Hormone Secretion
Kims Analysis
Language English
Sponsor Conselho Nacional de Pesquisa (CNPq)
AFIP (Associacao Fundo de Incentivo a Pesquisa)
Date 2016
Published in Journal Of Clinical Sleep Medicine. Westchester, v. 12, n. 4, p. 487-493, 2016.
ISSN 1550-9389 (Sherpa/Romeo, impact factor)
Publisher Amer acad sleep medicine
Extent 487-493
Origin http://dx.doi.org/10.5664/jcsm.5672
Access rights Closed access
Type Article
Web of Science ID WOS:000374140000005
URI http://repositorio.unifesp.br/handle/11600/49538

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