Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles

Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles

Author Leite-Silva, Vania R. Autor UNIFESP Google Scholar
Liu, David C. Google Scholar
Sanchez, Washington Y. Google Scholar
Studier, Hauke Google Scholar
Mohammed, Yousuf H. Google Scholar
Holmes, Amy Google Scholar
Becker, Wolfgang Google Scholar
Grice, Jeffrey E. Google Scholar
Benson, Heather A. E. Google Scholar
Roberts, Michael S. Google Scholar
Abstract Aim: We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (similar to 75 nm) in vivo. Materials & methods: Noninvasive multiphoton tomography with fluorescence lifetime imaging was used to evaluate the penetration of nanoparticles through the skin barrier and cellular apoptosis in the viable epidermis. Results: All nanoparticles applied to skin with flexing and massage were retained in the stratum corneum or skin furrows. No significant penetration into the viable epidermis was seen and no cellular toxicity was detected. Conclusion: Exposure of normal in vivo human skin to these nanoparticles under common in-use conditions of flexing or massage is not associated with significant adverse events.
Keywords Flexing
Human Skin In Vivo
Imaging
Massage
Nanoparticle Penetration
Zinc OxideFluorescence Lifetime
Zno Nanoparticles
Viable Epidermis
Hair-Follicles
Drug-Delivery
Dna-Damage
Cells
Sunscreen
Vitro
Keratinocytes
Language English
Sponsor National Health & Medical Research Council of Australia
Date 2016
Published in Nanomedicine. London, v. 11, n. 10, p. 1193-1205, 2016.
ISSN 1743-5889 (Sherpa/Romeo, impact factor)
Publisher Future medicine ltd
Extent 1193-1205
Origin https://doi.org/10.2217/nnm-2016-0010
Access rights Closed access
Type Article
Web of Science ID WOS:000374771100002
URI http://repositorio.unifesp.br/handle/11600/49526

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account