Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

Author Knittel, Luiza L. Autor UNIFESP Google Scholar
Schuck, Peter Google Scholar
Ackerson, Christopher J. Google Scholar
Sousa, Alioscka A. Autor UNIFESP Google Scholar
Abstract The natural tripeptide glutathione has become a popular choice for passivating the surface of gold nanoparticles (NPs) intended for in vivo applications. Here we investigate a zwitterionic derivative of glutathione - glutathione monoethyl ester - as a new capping ligand for ultrasmall NPs. The new zwitterionic particles (AuGSH(zwt)) were colloidally stable in biological media and resistant against binding from serum proteins. AuGSH(zwt), but not glutathione-coated particles, could be successfully functionalized with strep-tag II for binding specifically to target streptactin in the presence of serum proteins. Taken together, these results place AuGSH(zwt) as a promising choice for attaining simultaneous in vivo renal clearance and targeted delivery via incorporation of functional peptides.
Keywords Renal Clearance
Delivery
Surface
Tumors
Biodistribution
Nanoclusters
Systems
Size
Language English
Sponsor Sao Paulo Research Foundation (FAPESP) [2013/18481-5]
Brazilian National Council for Scientific and Technological Development (CNPq) [476784/2013-1]
Grant number FAPESP: 2013/18481-5
CNPq: 476784/2013-1
Date 2016
Published in Rsc Advances. Cambridge, v. 6, n. 52, p. 46350-46355, 2016.
ISSN 2046-2069 (Sherpa/Romeo, impact factor)
Publisher Royal soc chemistry
Extent 46350-46355
Origin http://dx.doi.org/10.1039/c6ra07777c
Access rights Closed access
Type Article
Web of Science ID WOS:000377254800036
URI http://repositorio.unifesp.br/handle/11600/49496

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