Control of stress-induced acth secretion by vasopressin and crh: additional evidence

Control of stress-induced acth secretion by vasopressin and crh: additional evidence

Author Ramos, Adriana T. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Troncone, Lanfranco R. P. Google Scholar
Abstract Vasopressin and CRH have complementary roles in the secretion of ACTH following different stress modalities. The concomitant use of V-1b and CRF1 receptor antagonists completely inhibits ACTH secretion in response to different stress modalities. The combination of the CRF1 antagonist SSR125543 with the V-1b antagonist SSR149415 effectively suppressed plasma ACTH 1.30 h after injection in rats stressed by ether vapor inhalation for 1 min, restraint stress for 1 h or forced swimming for 5 min. The duration of the effect was also studied. The CRF1 antagonist effectively suppressed ACTH secretion in restraint stress, while the V-1b antagonist was effective against ether inhalation. Both antagonists were necessary to block the forced swimming stress response. SSR125543 induced a prolonged effect and can be used in a model of prolonged HPA axis blockade. (C) 2016 S. Karger AG, Basel
Keywords Acth Secretion
Animal Models
Anxiety
Crf1 Receptor
Depression
Ether Inhalation
Forced Swimming
Restraint Stress
Vasopressin V-1b ReceptorV-1b Receptor Antagonist
Hydrochloride Ssr125543a
Disorders
Ssr149415
Antidepressant
Responses
Models
Suppression
Potent
Rats
Language English
Sponsor AFIP
FAPESP [98/14303-3, 04/12871-7, 15/08098-5, 2013/18897-7]
CAPES
Fundacao Butantan
Grant number Sanofi-Aventis: SSR125543
Sanofi-Aventis: SSR149415
FAPESP: 98/14303-3
FAPESP: 04/12871-7
FAPESP: 15/08098-5
FAPESP: 2013/18897-7
Date 2016
Published in Neuropsychobiology. Basel, v. 73, n. 3, p. 184-190, 2016.
ISSN 0302-282X (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 184-190
Origin https://doi.org/10.1159/000445480
Access rights Closed access
Type Article
Web of Science ID WOS:000377996400007
URI http://repositorio.unifesp.br/handle/11600/49493

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