Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases

Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases

Author Santana, Fernanda Paula R. Autor UNIFESP Google Scholar
Pinheiro, Nathalia M. Google Scholar
Mernak, Marcia Isabel B. Autor UNIFESP Google Scholar
Righetti, Renato F. Google Scholar
Martins, Milton A. Google Scholar
Lago, Joao H. G. Autor UNIFESP Google Scholar
dos Santos Lopes, Fernanda D. T. Q. Google Scholar
Tiberio, Iolanda F. L. C. Google Scholar
Prado, Carla M. Autor UNIFESP Google Scholar
Abstract Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effects in vitro and in vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.
Keywords Obstructive Pulmonary-Disease
Allergic Airway Inflammation
Smoke-Induced Emphysema
Intestinal Ischemia-Reperfusion
Elastase-Induced Emphysema
Rho-Kinase Inhibition
Asthma Murine Model
Antiinflammatory Activity
Language English
Sponsor CNPq [300546/2012-2, 304465/2012-7, 476877/2012-1]
FAPESP [2010/14831-3, 2011/15817-7, 2008/55359-5]
Grant number CNPq: 300546/2012-2
CNPq: 304465/2012-7
CNPq: 476877/2012-1
FAPESP: 2010/14831-3
FAPESP: 2011/15817-7
FAPESP: 2008/55359-5
Date 2016
Published in Mediators Of Inflammation. London, 2016.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Iop Publishing Ltd
Origin http://dx.doi.org/10.1155/2016/2348968
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000379440900001
URI http://repositorio.unifesp.br/handle/11600/49462

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