Acoustic rhinometry in nasal provocation tests in children and adolescents

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dc.contributor.author Wandalsen, G. F. [UNIFESP]
dc.contributor.author Mendes, A. L. [UNIFESP]
dc.contributor.author Matsumoto, F. [UNIFESP]
dc.contributor.author Sole, D. [UNIFESP]
dc.date.accessioned 2019-01-21T10:29:54Z
dc.date.available 2019-01-21T10:29:54Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.18176/jiaci.0036
dc.identifier.citation Journal Of Investigational Allergology And Clinical Immunology. Barcelona, v. 26, n. 3, p. 156-160, 2016.
dc.identifier.issn 1018-9068
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49461
dc.description.abstract Objectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents. Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5). Results: Compared with controls, patients with rhinitis had significantly higher mean total nasal resistance (0.34 Pa/cm(3)/s vs 0.21 Pa/cm(3)/s en
dc.description.abstract P=.01) and lower mean V5 values (8.20 cm(3) vs 9.24 cm(3) en
dc.description.abstract P=.04) at baseline. The mean histamine concentration necessary to increase total nasal resistance by at least 100% was significantly lower in the rhinitis group than in the control group (0.72 mg/mL vs 2.4 mg/mL en
dc.description.abstract P<.001). At the end of the NPT a mean increase of 126% in total nasal resistance and a mean decrease of 24.3% in V5 were observed in the rhinitis group. When compared with the AAR criteria, the highest sensitivity and specificity values were observed for a cutoff represented by a 19%-21% drop in V5. Conclusions: We found AR to be a feasible and sensitive tool for monitoring nasal response in children and adolescents undergoing histamine NPT. The best AR cutoff for ending the NPT was a 19%-21% drop in V5. en
dc.description.sponsorship FAPESP
dc.description.sponsorship CAPES
dc.format.extent 156-160
dc.language.iso eng
dc.publisher Hindawi Ltd
dc.relation.ispartof Journal Of Investigational Allergology And Clinical Immunology
dc.rights Acesso aberto
dc.subject Rhinitis en
dc.subject Nasal Provocation Tests en
dc.subject Histamine en
dc.subject Acoustic Rhinometry en
dc.subject Rhinomanometry en
dc.subject Nasal Cavity en
dc.subject Airway ResistanceAllergic Rhinitis en
dc.subject Challenge en
dc.subject Resistance en
dc.subject Patency en
dc.title Acoustic rhinometry in nasal provocation tests in children and adolescents en
dc.type Artigo
dc.description.affiliation Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifesp Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), Rua Otonis 725, BR-04025002 Sao Paulo, SP, Brazil.
dc.description.sponsorshipID This study was funded FAPESP and CAPES.
dc.identifier.doi 10.18176/jiaci.0036
dc.description.source Web of Science
dc.identifier.wos WOS:000379704800002



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