Acoustic rhinometry in nasal provocation tests in children and adolescents

Acoustic rhinometry in nasal provocation tests in children and adolescents

Author Wandalsen, G. F. Autor UNIFESP Google Scholar
Mendes, A. L. Autor UNIFESP Google Scholar
Matsumoto, F. Autor UNIFESP Google Scholar
Sole, D. Autor UNIFESP Google Scholar
Abstract Objectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents. Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5). Results: Compared with controls, patients with rhinitis had significantly higher mean total nasal resistance (0.34 Pa/cm(3)/s vs 0.21 Pa/cm(3)/s

P=.01) and lower mean V5 values (8.20 cm(3) vs 9.24 cm(3)

P=.04) at baseline. The mean histamine concentration necessary to increase total nasal resistance by at least 100% was significantly lower in the rhinitis group than in the control group (0.72 mg/mL vs 2.4 mg/mL

P<.001). At the end of the NPT a mean increase of 126% in total nasal resistance and a mean decrease of 24.3% in V5 were observed in the rhinitis group. When compared with the AAR criteria, the highest sensitivity and specificity values were observed for a cutoff represented by a 19%-21% drop in V5. Conclusions: We found AR to be a feasible and sensitive tool for monitoring nasal response in children and adolescents undergoing histamine NPT. The best AR cutoff for ending the NPT was a 19%-21% drop in V5.
Keywords Rhinitis
Nasal Provocation Tests
Histamine
Acoustic Rhinometry
Rhinomanometry
Nasal Cavity
Airway ResistanceAllergic Rhinitis
Challenge
Resistance
Patency
Language English
Sponsor FAPESP
CAPES
Grant number This study was funded FAPESP and CAPES.
Date 2016
Published in Journal Of Investigational Allergology And Clinical Immunology. Barcelona, v. 26, n. 3, p. 156-160, 2016.
ISSN 1018-9068 (Sherpa/Romeo, impact factor)
Publisher Hindawi Ltd
Extent 156-160
Origin http://dx.doi.org/10.18176/jiaci.0036
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000379704800002
URI http://repositorio.unifesp.br/handle/11600/49461

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