Repurposing of anti-diabetic agents for the treatment of cognitive impairment and mood disorders

Repurposing of anti-diabetic agents for the treatment of cognitive impairment and mood disorders

Author Cha, D. S. Google Scholar
Vahtra, M. Google Scholar
Ahmed, J. Google Scholar
Kudlow, P. A. Google Scholar
Mansur, R. B. Autor UNIFESP Google Scholar
Carvalho, A. F. Google Scholar
McIntyre, R. S. Google Scholar
Abstract Impairments in cognitive function represent a consistent, non-specific, and clinically significant feature in metabolic, mood, and dementing disorders. The foregoing observation is instantiated by evidence demonstrating that these disorders share pathophysiological mechanisms including, but not limited to, aberrant insulin signaling, inflammation, and glucocorticoid activity. Moreover, these mechanisms have been consistently reported to increase vulnerability to and/or exacerbate impairments in cognitive function. Notwithstanding evidence suggesting a bidirectional relationship between disturbances in the metabolic milieu, mood, and increased risk for dementia, efficacious treatments that target cognitive impairments in these populations do not presently exist. Taken together, it is proposed that anti-diabetic agents may aid the management of mood disorders and future risk for dementia through disease modification by targeting underlying pathophysiological mechanisms (e.g., aberrant metabolic function) rather than focusing solely on symptom mitigation. The current aim is to provide a brief narrative review of extant studies that report on the potential neurotherapeutic effects of anti-diabetic agents on disturbances in mood and impairments in cognitive function.
Keywords Depression
Bipolar
Diabetes
Dementia
Alzheimer's Disease
Insulin
Insulin Resistance
Glp-1
Incretin
Thiazolidinedione
Metformin
CognitionMajor Depressive Disorder
Activated Protein-Kinase
Glucagon-Like Peptide-1
Central-Nervous-System
Blood-Brain-Barrier
High-Fat-Diet
Type-2 Diabetes-Mellitus
Ppar-Gamma Ligands
Alzheimers-Disease
Insulin-Resistance
Language English
Date 2016
Published in Current Molecular Medicine. Sharjah, v. 16, n. 5, p. 465-473, 2016.
ISSN 1566-5240 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasil Polimeros
Extent 465-473
Origin http://dx.doi.org/10.2174/1566524016666160429121737
Access rights Closed access
Type Article
Web of Science ID WOS:000382639700004
URI http://repositorio.unifesp.br/handle/11600/49431

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