Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?

Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?

Autor Rodrigues, Mauricio Martins Autor UNIFESP Google Scholar
Alencar, Bruna Cunha Gondim de Autor UNIFESP Google Scholar
Claser, Carla Autor UNIFESP Google Scholar
Tzelepis, Fanny Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Intense immune responses are observed during human or experimental infection with the digenetic protozoan parasite Trypanosoma cruzi. The reasons why such immune responses are unable to completely eliminate the parasites are unknown. The survival of the parasite leads to a parasite-host equilibrium found during the chronic phase of chagasic infection in most individuals. Parasite persistence is recognized as the most likely cause of the chagasic chronic pathologies. Therefore, a key question in Chagas' disease is to understand how this equilibrium is established and maintained for a long period. Understanding the basis for this equilibrium may lead to new approaches to interventions that could help millions of individuals at risk for infection or who are already infected with T. cruzi. Here, we propose that the phenomenon of immunodominance may be significant in terms of regulating the host-parasite equilibrium observed in Chagas' disease. T. cruzi infection restricts the repertoire of specific T cells generating, in some cases, an intense immunodominant phenotype and in others causing a dramatic interference in the response to distinct epitopes. This immune response is sufficiently strong to maintain the host alive during the acute phase carrying them to the chronic phase where transmission usually occurs. At the same time, immunodominance interferes with the development of a higher and broader immune response that could be able to completely eliminate the parasite. Based on this, we discuss how we can interfere with or take advantage of immunodominance in order to provide an immunotherapeutic alternative for chagasic individuals.
Palavra-chave Chagas' disease
Trypanosoma cruzi
Immunodominance
Major histocompatibility complex
Idioma Inglês
Financiador Millennium Institute for Gene Therapy
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 2006/1983-4||FAPESP: 2003/09675-9
FAPESP: 2003/09672-0
FAPESP: 2004/110106-6
CNPq: 420067/2005-1
CNPq: 307151/2006-9
Data de publicação 2009-03-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 3, p. 220-223, 2009.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 220-223
Fonte http://dx.doi.org/10.1590/S0100-879X2008005000054
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000264200100001
SciELO S0100-879X2009000300001 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4942

Exibir registro completo




Arquivo

Nome: S0100-879X2009000300001.pdf
Tamanho: 64.20KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta