Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselen

Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselen

Author Petronilho, Fabricia Google Scholar
Michels, Monique Google Scholar
Danielski, Lucineia G. Google Scholar
Goldim, Mariana Pereira Google Scholar
Florentino, Drielly Google Scholar
Vieira, Andriele Google Scholar
Mendonca, Mariana G. Google Scholar
Tournier, Moema Google Scholar
Piacentini, Barbara Google Scholar
Della Giustina, Amanda Google Scholar
Leffa, Daniela D. Google Scholar
Pereira, Gregorio W. Autor UNIFESP Google Scholar
Pereira, Volnei D. Google Scholar
Teixeira Da Rocha, Joao Batista Google Scholar
Abstract Objetive: The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)(2) and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods: The effects of (PhSe)(2) and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results: Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)(2) improved this response. Moreover, the treatment with (PhSe)(2) decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. LB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions: The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)(2) more effective than EB. (C) 2016 Elsevier GmbH. All rights reserved.
Keywords Diphenyl Diselenide
Dss Induced-Colitis
Ebselen
Oxidative Stress
Ulcerative ColitisDextran Sulfate Sodium
Lipid-Peroxidation
Bowel-Disease
Animal-Models
Rats
Metabolism
Selenium
Injury
Damage
Language English
Date 2016
Published in Pathology Research And Practice. Jena, v. 212, n. 9, p. 755-760, 2016.
ISSN 0344-0338 (Sherpa/Romeo, impact factor)
Publisher Funpec-Editora
Extent 755-760
Origin https://doi.org/10.1016/j.prp.2016.04.012
Access rights Closed access
Type Article
Web of Science ID WOS:000383523500001
URI http://repositorio.unifesp.br/handle/11600/49400

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