Polymorphism of the cyp2d6 gene in women with breast cancer treated with tamoxifen

Polymorphism of the cyp2d6 gene in women with breast cancer treated with tamoxifen

Autor de Vasconcelos-Valenca, R. J. Google Scholar
Melo, M. A. Google Scholar
Lima, E. M. Google Scholar
de Sousa, G. V. Google Scholar
Nazario, A. C. Autor UNIFESP Google Scholar
da Silva, B. B. Google Scholar
Resumo Objective: To evaluate polymorphism frequency of the CYP2D6*4, *10, and *17 alleles in women with breast cancer treated with tamoxifen. Materials and Methods: Ninety-five women with estrogen and progesterone receptor-positive breast carcinoma were investigated from September to December 2013. A three-ml sample of peripheral blood was collected from each patient to analyze the presence of CYP2D6*4, *10, and *17 allele polymorphism by specific polymerase chain reaction technique (PCR) for analysis of haplotypes *1, *4, *10, and *17, determined by studies of different single-nucleotide polymorphism (SNP). The data obtained were compiled and analyzed with the aid of Excel software 2010. Results: The frequency of CYP2D6 alleles *4, *10, and *17 was 16%, 29%, and 2%, respectively, and haplotype *1/*10 was shown in 22% of the women. The phenotype of intermediate metabolism occurred in 8% of women. Conclusions: The present study showed a deficiency in tamoxifen metabolism, characterized by intermediate metabolism in 8% of Brazilian women.
Assunto Breast Cancer
Tamoxifen
Cyp2d6
Genetic PolymorphismAdjuvant Tamoxifen
Metabolism
Idioma Inglês
Data 2016
Publicado em European Journal Of Gynaecological Oncology. Montreal, v. 37, n. 5, p. 700-702, 2016.
ISSN 0392-2936 (Sherpa/Romeo, fator de impacto)
Editor Associacao Brasileira Pesquisa Pos-Graduacao Fisioterapia-Abrapg-Ft
Extensão 700-702
Fonte http://dx.doi.org/10.12892/ejgo3268.2016
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000385055500021
URI http://repositorio.unifesp.br/handle/11600/49387

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